Reduced glutathione (GSH) occurs naturally in all animal
cells; however, the liver is the largest reservoir in the body. GSH is a
cofactor for dozens of enzymes involved in detoxification and is
essential for phase I and phase II liver detoxification. Unfortunately,
conditions that negatively affect liver health usually result in
decreased concentrations of liver glutathione; for example, glutathione
levels are reduced in cats with hepatic lipidosis.
As a potent
endogenous antioxidant, GSH directly quenches several reactive oxygen
species. Animal structures and functions that can benefit from
maintaining normal levels of glutathione are numerous and include
hepatic, pulmonary, immune system, bowel, carbohydrate metabolism,
cardiovascular, cognitive, and eye health.
levels of glutathione appears to be important for supporting cognitive
function, especially as pets age. The normal process of aging is
associated with a decrease in glutathione regulation, which can result
in increased oxidative activity. Less than optimum levels of glutathione
are observed in animals experiencing a decline in cognitive function.
In humans, those living over 100 years tend to have higher glutathione
reductase activity – thus, higher glutathione levels.
mistaken belief is that glutathione is not well absorbed when taken
orally, but significant data confirms it is efficiently absorbed across
the intestinal epithelium by a specific uptake system. In the case of
GlutationeVET, Thorne Vet has gone a step further to assure efficient
absorption. Absorption of oral glutathione can be affected by stomach
acid or enzymes in the duodenum, which can break glutathione into its
amino acid components. However, the sustained-release properties of
GlutathioneVET protect it from stomach acid and digestive enzymes,
allowing slower release and a more steady blood level of this essential