CytoQuel® may have special dietary usefulness for promoting healthy cytokine function.
Current research has focused on the impact of pro-inflammatory cytokines on inflammation levels & chronic health conditions. During an infection, the body naturally produces pro-inflammatory cytokines as part of its defense mechanism. The healthy body balances pro-inflammatory cytokines with anti-inflammatory cytokines. However, if these pro-inflammatory cytokines (i.e. IL-1, IL-6, IL-8, IL-17, IL-23), Tumor Necrosis Factor-alpha (TNF-a), Nuclear Factor kappa Beta (NF-kß) continue in the “on position” and inflammation levels remain high, adverse health may be the result. Acute inflammation occurs almost immediately after trauma — from a cut or break, to a heart attack. Chronic inflammation is an ongoing process, breaking down or destroying tissue as it is repaired over and over.
CytoQuel® has been developed to promote healthy cytokine activity. Based on the latest published research, CytoQuel® offers you and your patients an effective new tool in the quest for healthy inflammation levels.
CurcuWIN Form of Curcumin
We have formulated this product with CurcuWIN™ turmeric extract, a new ingredient with published research showing absorption at a rate of 46 times standard curcumin and over 6 to 30 times greater than other enhanced curcumin products. This increased bioavailability advantage was consistently maintained for each of the twelve hours measured in this study. CurcuWIN combines curcumin with a hydrophilic (allowing it to disperse in water) carrier, using the UltraSOL™ molecular dispersion technology. UltraSOL converts lipophilic (fat loving or fat absorbing) nutrients into water-dispersible ingredients. Curcumin is notoriously hydrophobic (not absorbed in water). It creates clumps when placed in water. The clumps reduce the body’s ability to efficiently utilize the nutrient. CurcuWIN™ utilizes the UltraSOL™ technology platform creating a molecular dispersion, which is another way of saying this technology creates incredibly small particles. The micro particles are then coated with food-grade excipients and antioxidants to protect and stabilize curcumin. The excipients facilitate better dispersion in aqueous solution while the antioxidants protect and facilitate more efficient utilization within the body. Curcumin (turmeric extract) is a favorite of doctors who want to promote healthy inflammation levels.
Testing for Inflammation
Generalized inflammation testing is available for doctors and their patients. The most commonly mentioned test is C-reactive protein (CRP). Elevated CRP-levels can be measured in blood in response to inflammation. Initially used solely as a marker for potential cardiovascular risk, it is now a marker to measure ongoing inflammation in the body. The CDC and American Heart Association consider low inflammation if the CRP is less than 1.0 mg/L, with high risk being above 3.0 mg/L. Many doctors use the CRP or the highly sensitive CRP (hs-CRP) test as an indicator of inflammation. If patients are elevated, doctors often times council patients on lifestyle changes (i.e. diet, exercise). They may also turn to pharmaceutical and/or nutraceuticals to promote a healthy change.
Black Tea Extract
- The anti-inflammatory effects of green and black tea polyphenols have been substantiated by dozens of in vitro and animal studies (Singh et al. 2010)
- The polyphenols EGCG and theaflavin exert their anti-inflammatory effects through the inhibition of the NF-Kß signaling pathway, which decreases expression of several inflammatory proteins (lipoxygenase, cyclooxygenase, TNF-a, IL-1ß, IL-6, and IL-8) in cell culture experiments (de Mejia et al. 2009).
- EGCG also inhibits the production and release of histamine, a key mediator of allergic and inflammatory response, in vitro (Melgarejo et al. 2010).
- In observational studies of tea consumption, >2 cups of tea/day (black or green) was associated with a nearly 20% reduction in CRP compared to non-tea drinkers, and significantly lower levels of two other inflammatory markers (serum amyloid A and haptogen, which are elevated in coronary heart disease) (De Bacquer et al. 2006).
- In clinical interventions, black tea appears to be more successful in reducing inflammatory markers than green (Galland 2010).
- A 25% reduction in CRP was also observed in a small trial of healthy, non-smoking men consuming a black tea extract (equivalent to 4 cups of tea/day) for 6 weeks (Steptoe et al. 2007).
- A similar average reduction was observed in a larger study of healthy, individuals at high risk for coronary heart disease, but revealed a more dramatic 40-50% reduction in CRP amongst individuals with the highest starting CRP values (>3 mg/L) (Bahorun et al. 2010).
N Acetyl Cysteine
- Activation of the NF-KB pathway plays a central role in the activation of inflammatory cytokine genes; N-acetyl cysteine inhibits NF-Kß in cell culture, lowering expression of cytokines such as IL-6 and IL-8 (Araki et al. 2007) (Radomska-Lesniewska et al. 2006).
- NAC supplementation for 8 weeks demonstrated modest, but statistically significant decreases in circulating IL-6 levels in patients with chronic kidney disease (Nascimento et al. 2010). The effects were more pronounced in persons with significant inflammation at the start of the study (as measured by hs-CRP).
- NAC also reduced markers of systemic inflammation in a small study of patients with burn injuries (Csontos et al. 2011).
- Extensive in vitro and animal studies have examine the effects of curcumin on experimentally-induced inflammatory diseases (atherosclerosis, arthritis, diabetes, liver disease, gastrointestinal disorders, and cancers) and disease markers (lipoxygenase, cyclooxygenase, TNF-a, IL-1ß, NF-Kß, and others) (Chainani-Wu 2003, Bengmark 2006).
- Fewer human studies have examined curcumin’s effects on patient-oriented outcomes in inflammatory diseases, but most of the small randomized controlled trials of curcumin have consistently shown patient improvements in several inflammatory diseases, including psoriasis, irritable bowel syndrome, rheumatoid arthritis, and inflammatory eye disease (Epstein et al. 2010)(reviewed in White et al. 2011).
- Tocotreinol-rich fraction (TRF) possesses potent anti-inflammatory activity, and its mechanism of action could be through the inhibition of iNOS and COX-2 production, as well as NF-kappaB expression. Tocotrienol-rich fraction oil exhibits anti-inflammatory property by suppressing the expression of inflammatory mediators in human monocytic cells. Mol Nutr Food Res. 2008 Aug;52(8):921-9.
- The exact mechanism by which resveratrol exerts anti-inflammatory activity has not been established, although it inhibits a variety of pro-inflammatory compounds (cyclooxygenase, TNF-a, IL-1ß, IL-6, NF-Kß) in animal models and human cell culture (Jha et al. 2010; Khanduja et al. 2004).
- The related compound pterostilbene has demonstrated similar inhibition of inflammatory markers in cell culture (Pan et al. 2008).
- Modulation of the inflammatory immune response likely contributes to resveratrol’s protective role in animal models of heart disease, cancer, acute pancreatitis and inflammatory bowel disease (Clarke et al. 2008).
- Resveratrol may be protective against general, low-level para-inflammation as well: when taken with a single high-fat, high-carbohydrate meal (930 kcal), resveratrol (100 mg) prevented the sharp post-meal increases in markers of oxidation and inflammation in a small crossover study of 10 healthy volunteers. For example, synthesis of IL-1ß increased by 91% over 5 hours following the test meal; with resveratrol, this increase was significantly less (29%) (Ghanim et al. 2011).
- New evidence shows how resveratrol reduces production of inflammatory molecules such as leukotrienes by inhibiting the enzymes that produce them. Chatterjee M, Das S, Janarthan M, Ramachandran HK.
- Role of 5-lipoxygenase in resveratrol mediated suppression of 7,12-dimethylbenz(alpha)anthracene-induced mammary carcinogenesis in rats. Eur J Pharmacol. 2011 Oct 1;668(1-2):99-106 & Oi N, Jeong CH, Nadas J, et al.
- Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene ahydrolase. Cancer Res. 2010 Dec 1;70(23):9755-64.