Boluoke® (lumbrokinase) is the only fully researched oral fibrinolytic
supplement on the market. Besides having in vitro studies, animal
studies, toxicity studies, and pharmacokinetic studies done, Boluoke®
has also been put through all phases of clinical trials (including
randomized double blind controlled studies) in China. Lumbrokinase has
been studied as a treatment for various clinical conditions, including
acute, sub-acute, and chronic conditions that are associated with the
presence of hypercoagulation and hypoperfusion.
Lumbrokinase is a more potent enzyme preparation than nattokinase. One
of the advantages of Boluoke® (lumbrokinase) is that it does not
interfere with the clotting cascade, but instead, works by reducing
fibrinogen and fibrin. Boluoke® does not affect INR or aPTT, thus is
compatible with Coumadin® or heparin.
Boluoke® vs. Other Lumbrokinase Products
lumbrokinase products to Boluoke® is like comparing apples and oranges.
Boluoke®’s enzymatic strength is standardized against urokinase and
t-PA. The imitation products are likely just earthworm protein extract
containing little pure lumbrokinase or lumbrokinase of low enzymatic
strength. Some companies are making products with 230mg to 250mg of
lumbrokinase per capsule and trying to quote Boluoke®’s research as
their own. Boluoke®’s capsules are of 200mg in size, and contain 20mg of
lumbrokinase inside each capsule. Most of these other lumbrokinase are
unable to distinguish between the weight of the capsule (i.e. 250 mg)
and the active lumbrokinase per capsule (Boluoke® is 20 mg).
Boluoke® is the only fully researched oral fibrinolytic supplement on
the market. Besides having in vitro studies, animal studies, toxicity
studies, and pharmacokinetic studies done, Boluoke® has also been put
through all phases of clinical trials (including randomized double blind
controlled studies) in China. Boluoke® is the only Lumbrokinase that
is backed by Phase I – III clinical trials in China, the one that is
first used in hospitals in China, and covered by the Chinese National
Fundamental Health Insurance.
A common question we receive is about potential side effects of
Boluoke®. The earthworm has been used in Traditional Chinese Medicine
for a few thousand years, and is considered to be one of the safest
medicines in the traditional pharmacopoeias. In one of the largest
clinic trials of Boluoke® involving 16 hospitals and 1560 patients in
China, the overall adverse reaction rate was 1.92% (30 cases). 0.58% had
skin itching, 0.19% had skin rash, and 1.15% had nausea or diarrhea; no
hemorrhage or major side effect was reported. Again, this research pertains only to Boluoke®.
It is interesting that other lumbrokinase products cite the clinical
results achieved with only Boluoke®, confusing the reader into assuming
that the research was done on their formulations. However, their
products may be very different, and your patients may have very
On the raw material market, the price of lumbrokinase can vary by up to
15 fold, and the enzymatic strengths of various Lumbrokinase also differ
greatly. In addition, lumbrokinase is a preparation containing multiple
enzyme fractions, and the extraction and purification method determines
the composition of the various enzyme fractions. Thus different
extraction methods will produce different sub-fractions of lumbrokinase.
This is the reason why Boluoke® does not significantly change
prothrombin time (PT) or activated partial thromboplastin time (aPTT),
while other lumbrokinase sources may significantly alter PT or aPTT as
shown in studies. No other lumbrokinase product can provide you with
Boluoke® seems to be beneficial for any
illness that has an accompanying hypercoagulable blood state, which has
been shown to be present in many chronic illnesses. Some practitioners
are also recommending Boluoke® for those who choose to be on hormone
replacement therapy or birth control pills, and for those who could not
tolerate standard preventative pharmaceutical drugs.