A revolutionary enzyme product from Kirkman®
The human intestinal tract contains seven enzymes that split dietary
disaccharides into free monosaccharides. Until now, commercially
available enzyme products contained enzyme ingredients that had the
activity of only some of these disaccharidase enzymes. One in
particular, however, sucrase-isomaltase complex, was only partially
represented in these products. Invertase is present in these products
to hydrolyze sucrose to yield glucose and fructose, and to hydrolyze
other complex sugars that contain fructose, so it acts as a sucrase
enzyme. The isomaltase fraction of that human enzyme is not represented
because there is no commercially available form of isomaltase in the
The importance of this missing enzyme fraction was confirmed in January
2004 by R. Kushak, Ph.D., and T. Buie, M.D., of Massachusetts General
Children’s Hospital in an intestinal biopsy study involving 100 children
with special requirements and sensitivities. The study showed that 60%
of these patients had weak lactase activity and 25-45% had weak
isomaltase/palatinase activity, which substantiated their special
dietary need for an enzyme providing isomaltase/palatinase activity.
This study provided the impetus for Kirkman® to search for an enzyme
that had isomaltase/palatinase activity. Kirkman® found that enzyme and
trademarked it Isogest®.
Isogest® has the ability to split isomaltose into two molecules of
glucose and to split palatinose into one molecule of glucose and one
molecule of fructose. The result of including this new enzyme is
better, more complete carbohydrate digestion. Currently, no other
enzyme product can offer this added activity.
EnZym-Complete/DPP-IV™ II with Isogest® is Kirkman’s second generation
version of Enzym-Complete/DPPIV™. It contains all the enzymes present
in Enzym-Complete/DPPIV™ plus Isogest®. The presence of Isogest® gives
this product the equivalent activity of the isomaltase fraction of the
sucrase/isomaltase enzyme found in the human digestive system.
Individuals currently using Enzym-Complete/DPPIV™ who are getting
partial results and still need some improvement or individuals using
other enzymes who are not completely satisfied with the results should
try EnZym-Complete/DPP-IV™ II with Isogest® formula.
Physicians and parents who evaluated products containing Kirkman’s Isogest® reported the following:
No adverse effects were reported.
- less bloating
- more regular bowel habits
- less constipation
- more normal stools
- better overall digestion with less discomfort
- firmer stools
- less gas
- less diarrhea
- less sensitivity to dairy and grains
- less odorous bowel movements