A first of its kind study from Harvard Medical School and
Massachusetts General Hospital shows that the supplement that S-Adenosyl
Methionine (SAMe), can be an effective support for patients with major
depressive disorders who do not respond to their antidepressant
medication. According to the investigators, led by George I. Papakostas,
MD, of the Center for Treatment-Resistant Depression at Massachusetts
General Hospital and Harvard Medical School in Boston, SAM-e treats
depression. During the study, significantly more SAMe-treated than
placebo-treated patients experienced a clinical response on the 17-item
Hamilton Depression Rating Scale (HAM-D), which was the primary study
outcome. Remission rates were also higher with SAMe than with placebo.
“With each study we continue to gain a better understanding of
SAM-e’s role in treating depression. This new finding, albeit
preliminary and in urgent need of replication, suggests significant,
clinically meaningful differences in outcome among patients who had
SAM-e added to their antidepressant medication treatment compared to
those taking a placebo with their medication.”
For Liver Support, Depression and Arthritis
Classified as a prescription drug in Germany, Russia, Italy, and Spain, SAMe has been the subject of studies on depression at Harvard Medical School,
the University of California, and King’s College Hospital in London.
What these studies have shown is that SAMe influences brain chemicals by
helping to convert the feel-good neurotransmitters norepinephrine into
epinephrine, and serotonin into melatonin. It is also involved in the
formation of myelin, the white sheath that surrounds nerve cells. It can
improve brain-cell membrane fluidity.
Not an herb, or even a vitamin, SAMe is a substance produced in every
living organism on the planet. In fact, our bodies produce about eight
grams of SAMe per day. More than half of that amount is produced in the
liver. For this reason it has been used effectively as support for liver
disease, especially alcohol-induced damage. (See the anti-alcohol
But there is so much more to know about SAMe than its mood enhancing
effects. Click on the links below and read all about what it does for
osteoarthritis and liver disease as well.
Each bottle contains 60 tablets and each tablet contains 400mg, twice the amount of other manufacturers.