Hormone Combination - formulated to provide relief from menstrual and cyclic related symptoms including emotional swings, depression, headache, irritability, cravings and fluid retention. A Source of Relief for PMS In 1983 a medical doctor, D.W. Remington, and his associate, Robert Gardner, Ph.D., began researching hormone supplements attempting to determine and solve the underlying causes of PMS. They administered serial dilutions of Estrogen and Progesterone sublingually. These were found to neutralize PMS and other cyclical symptoms. Even chronic PMS symptoms were relieved, sometimes dramatically. A problem, however, arose in finding a neutralizing dose. The effective dose often changed, requiring constant monitoring and adjustments for each patient. Their proposed therapy was to initiate hormone treatment at a high concentration and progressively move to lower concentrations. Many patients realized positive results with this system; however, the results were unpredictable. At times, patients would react negatively to a concentration that had formerly controlled symptoms. The team began researching methods to deliver treatment that would stabilize the patient on one dosage amount for extended periods of time. Imagine their surprise when they discovered that the most stable results were realized only when the dilutions reached homeopathic levels! Their labors led them to the development of Hormone Combination. This product includes a group of hormones in multiple homeopathic dilutions administered together (called a homochord) -a combination that was found to clear symptoms each time, as well as stabilize the patients long-term. Hormone Combination made it possible to administer a standard dose to each patient with confidence in the expected outcome. Why it Works At first, it was assumed that the right concentration of the combined hormones somehow stopped or shut off an inappropriate immune response to the hormone. Further perspective indicated that Hormone Combination works through other systems in addition to affecting the immune system. A double-blind study was performed using tryptophan (an amino acid), nicotinamide (a B vitamin), imipramine or a tryptophan-nicotinamide-imipramine. This combination given to severely depressed people helped provide further understanding as to why Hormone Combination works. Observations showed that some doses of tryptophan-nicotinamide-imipramine worked very well, but smaller or larger doses did not. This was the effective dose range or "therapeutic window." This window may really be the result of immune modulation or regulation. It was determined that immune modulation might apply to body chemicals, microorganisms, substances in foods, and, in fact, to all substances that find their way into the body. It has been observed that many sensitive patients have an intolerance to serotonin, epinephrine, progesterone, glucose and other substances that further complicate their response to foods, pollens, chemicals and even emotional stress. This intolerance may result from the natural cycles in the levels of hormones, food chemicals, etc., being outside the range the immune system can handle. This could mean the cycling levels of hormones are outside the tolerable "therapeutic window" dictated by immune modulation. Hormone Combination appears to have the effect of widening the permissible range in which the natural cycles of changing hormone amounts in the system can operate without symptoms. As mentioned, women can experience improvements so quickly from taking Hormone Combination that the next menstrual cycle may occur with no symptoms or warnings. For a few, the first cycle following administration of Hormone Combination can involve changes -even slight worsening - of some symptoms. When this happens, the second cycle will generally be much improved. No adverse side effects from the therapy have been reported. ESTRADIOL 6X, 12X, 30X, 60X, 200X, 12C, 30C, 60C, 200C: Secreted chiefly by the ovaries. Most potent estrogen; critical impact on reproductive and sexual functions; affects bone structure. ESTRONE 6X, 12X, 30X, 60X, 200X, 12C, 30C, 60C, 200C: An estrogenic hormone secreted by the ovary; found chiefly as a metabolite of estradiol. ESTRIOL 6X, 12X, 30X, 60X, 200X, 12C, 30C, 60C, 200C: A reduction product of estrone and estradiol. DHEA is converted to estriol by the placenta. Levels are usually stable after menopause. FSH 12, 30C, 60C, 200C: "Follicle-stimulating hormone" produced by the pituitary that, in females, regulates the levels of estrogen and progesterone. ALDOSTERONE 12C, 30C, 60C, 200C: A steroid hormone produced by the outer-section of the adrenal cortex that regulates electrolytes and water balance. PROGESTERONE 6X, 12X, 30X, 200X, 12C, 30C, 60C, 200C: Influences the preparation of the uterus for the reception and development of the fertilized ovum. TESTOSTERONE 6X, 12X, 30X, 200X, 12C, 30C, 60C, 200C: A steroid hormone from the androgen group associated with libido in males and females; lower levels produced in females. HYDROCORTISONE 6X, 12X, 30X, 200X, 12C, 30C, 60C, 200C: The major glucocorticoid produced by the adrenals that has life-maintaining and blood pressure-sustaining properties. LH 12X, 30X, 200X: Luteinizing hormone (LH), also known as lutropin, synthesized and secreted by gonadotropes in the anterior lobe of the pituitary gland. ANDROSTERONE 12C, 30C, 60C, 200C: Abbreviated as "ADT" is a steroid hormone with weak androgenic activity. It is made in the liver from the metabolism of testosterone. DHEA 6X, 12X, 30X, 200X, 12C, 30C, 60C, 200C: "Dehydroepiandrosterone" - a hormone produced primarily by the adrenal glands is the most abundant hormone in the human body. CHOLESTEROL 6X, 12X, 30X, 200X, 12C, 30C, 60C, 200C: Plays a central role in many biochemical processes. Needed to build and mainain cell membranes. SALSOLINOL 6X, 12X, 30X, 200X: Included to address ethanol sensitivity and to relieve depression, vascular headache and to aid memory.